Played for the Los Angeles/Oakland Raiders and the Carolina Panthers. Skrepenak's professional football career spanned the final three years the Raiders played in Los Angeles, California from 1992-1994 and the first year they returned to Oakland, California in 1995. Then, it continued with consecutive seasons (1996 and 1997) with the Carolina Panthers in which he did not miss a start.
Prior to his NFL experience Skrepenak had starred in the Big Ten football conference for the University of Michigan Wolverines as a two-time All-American, team captain, and four-year starter from 1988-1991. Skrepenak played for four consecutive Big Ten Conference Champions, appeared in three Rose Bowls and won a Gator Bowl MVP. Previously he had been a scholar athlete at G. A. R. Memorial Junior Senior High School where he earned 12 varsity letters in football, basketball and baseball.
Skrepenak, who was born and raised in Wilkes-Barre in Luzerne County, Pennsylvania, United States, was elected in 2003 to serve as the Luzerne County Commissioner, a position he has held since January 2004. Skrepenak was re-elected on November 6, 2007. He had considered running for the United States House of Representatives in the 2006 elections, but decided against running for such an office this early in his political career. On December 17, 2009, Greg Skrepenak signed a plea agreement to a charge of corruption. He would resign later that day. On August 6, 2010, Greg Skrepenak was sentenced to 24 months in federal prison.